Remember, you need at least one selected topic to use HealthSavvy. Laboratory evaluation for adrenal insufficiency and replacement stress doses of a rapidly acting glucocorticoid may be indicated for such patients. Megestrol acetate is not intended for prophylactic use to avoid weight loss. Are you still sure that you want to clear all of you selected topics? The information may not cover all possible uses, actions, interactions, or side effects of this drug, or precautions to be taken while using it. . In female monkeys, no tumors were found following 10 years of treatment with 0. Reduction in fetal weight and number of live births were observed at 12.
Journal of the American Chemical Society. Adults Dosage has not been established. Don't change your dose without first talking to your physician. Median T max value was five hours. There are no adequate and well-controlled studies in pregnant women. Weight gain occurs within 3 weeks in most patients who receive megestrol for this purpose.
Every effort has been made to ensure that the information provided by on this page is accurate, up-to-date, and complete, but no guarantee is made to that effect. The possibility of adrenal suppression should be considered in any patient taking or withdrawing from chronic megestrol therapy who presents with symptoms of adrenal insufficiency e. Mean weight changes at 4, 8 and 12 weeks for patients evaluable for efficacy in the two clinical trials are shown graphically. Plasma concentrations are dependent, not only on the method used, but also on intestinal and hepatic inactivation of the drug, which may be affected by factors such as intestinal tract motility, intestinal bacteria, antibiotics administered, body weight, diet and liver function. Its is 34 hours on average, with a range of 13 to 105 hours. In addition, clinical cases of adrenal insufficiency have been observed in patients receiving or being withdrawn from chronic megestrol therapy in the stressed and non-stressed state. It has been found to possess 30% of the affinity of the for this receptor.
Pituitary tumors were observed in female rats treated with 3. Megace can pass into body fluids such as urine, feces, vomit, semen, and vaginal fluid. Dialysis Data not available Other Comments A minimum of two months of continuous treatment is considered to be an adequate period for determining the efficacy of megestrol tablets. In , limited reports of have been received. The American Journal of Geriatric Pharmacotherapy. Some people may be given this lower dose. It's prescribed by veterinarians under the brand name Ovaban.
The medication is in the mainly by of the C21, C2α, and C6 positions, as well as by and. Missed Dose of Megace If you miss a dose of Megace, take it as soon as you remember. Respiratory excretion as labeled carbon dioxide and fat storage may have accounted for at least part of the radioactivity not found in urine and feces. Solubility at 37°C in water is 2 mcg per mL, solubility in plasma is 24 mcg per mL. In case of overdose, appropriate supportive measures should be taken. In female beagles, megestrol acetate 0. For more specific information, consult with your doctor or pharmacist for guidance based on your health status and current medications, particularly before taking any action.
Finally, in patients who are receiving or being withdrawn from chronic megestrol therapy, consideration should be given to the use of empiric therapy with stress doses or a rapidly acting glucocorticoid in conditions of stress or serious intercurrent illness e. These treatable causes include possible malignancies, systemic infections, gastrointestinal disorders affecting absorption, endocrine disease, renal disease, or psychiatric disease. Progesterone was studied in the treatment of breast cancer in 1951 and 1952, but with relatively modest results. Administration of megestrol acetate to female dogs for up to 7 years is associated with an increased incidence of both benign and malignant tumors of the breast. It's also used to treat false pregnancies, behavioral problems, skin disorders, and other health issues in pets.
The usual recommended dosage for reducing the symptoms of endometrial cancer is between 40 mg and 320 mg a day, given as several doses throughout the day. Failure to recognize inhibition of the hypothalamic-pituitary-adrenal axis may result in death. Warfarin: Moderate At high doses, megestrol may be associated alterations in warfarin pharmacokinetics that may increase warfarin exposure. There are no available human data to assess for any drug associated risks of miscarriage, birth defects, or adverse maternal or fetal outcomes. It does not appear to be marketed in , , , , , or , among other countries.
The specific megestrol dosage your healthcare provider recommends will depend on the particular product you are using, the reason you are taking it, and various other factors. The usual recommended dosage for reducing the symptoms of endometrial cancer is between 40 mg and 320 mg a day, given as several doses throughout the day. Peak concentrations after administration of the suspension are reached in approximately 3—5 hours; peak concentrations for the tablets are reached in 1—3 hours. Pregnancy Megestrol is contraindicated during pregnancy. If megestrol is used during pregnancy, or if the patient becomes pregnant while taking megestrol, advise the patient of the potential hazard to the fetus. Prior to use of megestrol, confirm that a female of childbearing potential is not pregnant.
Some people may be given this lower dose. In post-marketing experience, limited reports of overdose have been received. Med Clin Barc in Spanish. Your specific dosage, however, will depend on the product you are using, how you respond to it, and the reason you are taking the drug, among other factors. Reproduction studies were performed in pregnant rats at oral doses ranging from 0. Ask your pharmacist if you don't have this item. It may also cause side effects such as -like symptoms, , and at high dosages.
The drug induces endometrial secretory changes, increases basal body temperature, inhibits pituitary function, and precipitates bleeding when estrogen is present. Doses of 400 mg a day were also effective in clinical trials 10 mL of megestrol suspension. Laboratory evaluation for adrenal insufficiency and consideration of replacement or stress doses of a rapidly acting glucocorticoid are strongly recommended in such patients. Coadministration of entecavir with antiviral drugs known to be eliminated by active tubular secretion did not result in significant drug interactions in studies Indinavir: Major Due to the significant decrease in the exposure of indinavir by megestrol acetate, administration of a higher dose of indinavir should be considered when coadministering with megestrol acetate. Based on animal studies, megestrol may cause fetal harm when administered to pregnant women.